Dr. Kaluka publishes paper in PNAS

Posted by Fernando.Arzola on Wednesday October 8, 2014


Dr. Daniel Kaluka, Assistant Professor of Chemistry, in collaboration with colleagues from the University of Illinois and Albert Einstein College of Medicine, has published a research article entitled “Conformational coupling between the active site and residues within the KC-channel of the Vibrio cholerae cbb3-type (C-family) oxygen reductase,” in the Proceedings of the National Academy of Sciences (PNAS 2014; published ahead of print October 6, 2014, doi:10.1073/pnas.1411676111).

PNAS is one of the world's most-cited and comprehensive multidisciplinary scientific journals, publishing more than 3,800 research papers annually. Established in 1914, PNAS publishes cutting-edge research, science news, Commentaries, Reviews, Perspectives, Colloquium Papers, and actions of the National Academy of Sciences.

The research is focused on characterization of the proton channel of a bacterial reductase enzyme (cbb3) utilizing site-directed mutagenesis, molecular dynamics simulation and resonance Raman spectroscopic techniques. Cbb3, though it exhibits some similarities with the human cytochrome c oxidase (the terminal enzyme in the respiratory chain), it has some notable differences that potentially can be exploited in developing selective drugs. Dr. Kaluka's piece of the pie involved employing resonance Raman Spectroscopy (at Albert Einstein College of Medicine) in deciphering the structural features of the protein linked to the proton channel.

Details of the paper can be found here:

http://www.pnas.org/content/early/2014/10/03/1411676111.abstract?sid=0470a77f-10a2-4486-b865-8d066969919

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